Nitric Oxide has provided one of the biggest biological surprises. It has recently been shown to be an important messenger in many Vertebrate signal transduction processes. This free radical gas has been identified in the human brain and detected in exhaled breath.
NO is a vital and the first gaseous biological messenger to be identified. It diffuses freely across membranes, but has a short life less than a few seconds, because it is highly reactive. Hence, NO is well suited to serve as a transient signal molecule within cells and between adjacent cells.
Nitric Oxide is produced in the brain and serves as a neuro transmitter. It causes muscle cells to dilute and relax. It acts as a mediator of blood vessel relaxation and thus brings down blood pressure. This function is partly brought about by the activation of guanyl cyclase. Its formation is regarded as the main determinant of blood pressure in many species, including man.
Nitric oxide also participates in the transmission of nerve impulses, which is important in a range of activities, including gut contraction and food movement as well as penile erection.
NO is an effective killer of cells (Cytotoxic) or blocker of cell multiplication and growth (Cytostatic). It's known antibacterial activity possibly occurs via the generation of other radicals.
There are three variety of inhibitor of NO3 action and there may be of value in the treatment of certain clinical conditions arising from irregular production of NO.
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